I had seen that there is a "minimum city distance" setting in the configuration file.
As i experienced at least with older versions, when new factories open, they will open in a short distance around a city. This annoys me a bit, as i like if things are relatively far from each other, so i have space to design routes (I even set city distance to 64 or 96). Can not factories have a similar setting defining how far they can be placed from the city in which the end of the chain opens?
(This way everyone could use a metric suiting his/her own desires. If someone likes to have lots of space, long trains, and such, may set this two factors higher, and play on larger maps, while ones who like as it now, could keep these low)